Inducing targeted protein degradation : from chemical biology to drug discovery and clinical applications /
| Other Authors: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
2023.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Targeted Protein Degradation - The Story So Far / Daniel H O Donovan, Laura M Luh, Philipp M Cromm
- Cellular Principles of Targeted Protein Degradation / João Diamantino, Doris Hellerschmied
- E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug Development / Rafael M Ioris, Katherine Ferris, Vincenzo D'Angiolella
- A Structural and Biophysical Perspective of Degrader Activity Through Ternary Complex Formation / Morgan S Gadd, Marine C Aublette
- Computational Modeling of PROTAC Ternary Complexes and Linker Design / Sven A Miller, Grigorii V Andrianov, Victoria Mischley, Khadija A Wharton, Jesse J Chen, John Karanicolas
- Molecular Glue Degraders: From Serendipity to Hunting and Design / Luis Nieto-Barrado, Ana Domostegui, Cristina Mayor-Ruiz
- Targeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases / Fleur M Ferguson
- Insights and Future Perspectives of Covalent Protein Degraders / Xiaoyu Zhang
- Extending the Degradation Toolkit - mRNA Targeting as an Alternative Means to Affect Protein Levels / Andrei Ursu, Barbara Herdy, Hendrik Osadnik
- The Future of Heterobifunctional Compounds: PROTACs and Beyond / George M Burslem
- Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery / Paola Martinelli, Christiane Kofink, Georg Boeck, Harald Weinstabl, Manfred Koegl
- Taming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders / Caroline Rynn, Arthur Van De Vyver, Antje Walz, Carina Cantrill, Matthias Wittwer
- PROTAC ® Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates / Erika MV Araujo, Keith R Hornberger.