Animal models for human cancer : discovery and development of novel therapeutics /

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion...

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Bibliographic Details
Other Authors:	Martic-Kehl, Marianne I. (Editor), Schubiger, P. A. (Editor)
Format:	eBook
Language:	English
Published:	Weinheim, Germany : Wiley-VCH, 2016.
Series:	Methods and principles in medicinal chemistry ; vol. 69.
Subjects:	Animal models in research. Veterinary pharmacology. Diseases > Animal models. Antineoplastic agents. Antimitotic agents. Disease Models, Animal Antineoplastic Agents Drug Discovery Antimitotic Agents Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Chapter 1. Introduction
Chapter 2. Ethical aspects of the use of animals in translational research
Chapter 3. Study design
Chapter 4. Improving external validity of experimental animal data
Chapter 5. How to end selective reporting in animal research
Chapter 6. A comprehensive overview of mouse models in oncology
Chapter 7. Mouse models of advanced spontaneous metastasis for experiemental therapeutics
Chapter 8. Spontaneous animal tumor models
Chapter 9. Dog models of naturally occurring cancer
Chapter 10. Improving preclincal cancer models: lessons from human and canine clinical trials of metronomic chemotherapy.