Lead generation : methods, strategies, and case studies /
| Other Authors: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Weinheim :
Wiley-VCH,
[2016]
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| Series: | Methods and principles in medicinal chemistry ;
v. 68, a-b. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann
- Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown
- The Importance of Target Identification for Generating Successful Leads. Ligandability of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze
- Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi
- Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange
- Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson
- Rational Hit Generation / Bernd Wellenzohn, Alexander Weber
- Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang
- Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann
- Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li
- Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell
- Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown
- Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak
- Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner
- Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt
- Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page
- Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown
- Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins
- Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah
- Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz
- GPR81 HTS Case Study / Eric Wellner, Ola Fjellström
- Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein
- The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski
- Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko
- A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda.