rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular immunotoxicology
  name:
    name part: Corsini, Emanuela.
  name:
    name part: Loveren, Henk van.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: gw
    place:
      place term: Weinheim
    publisher: Wiley-VCH
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models.Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic e.
  table of contents: Molecular Immunotoxicology; Contents; Preface; List of Contributors; Chapter 1 The Evolution of Immunotoxicology; 1.1 Introduction; 1.2 Immune-Mediated Environmental Lung Diseases; 1.3 Immunotoxic Drug Reactions; 1.4 Autoimmunity; 1.5 Immunosuppression; 1.6 Allergic Contact Dermatitis (ACD); 1.7 Summary; References; Chapter 2 Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity; 2.1 Introduction; 2.2 Mechanisms of Immunotoxicity; 2.2.1 Interference with Cellular Signaling; 2.2.1.1 Receptor-Mediated Immunotoxicity; 2.2.1.2 Non-receptor-Mediated Immunotoxicity.
  table of contents: 2.2.2 Adducts Formation and Role of ROS2.3 Conclusions; References; Chapter 3 Use of Toxicogenomics in Immunotoxicology; 3.1 Introduction; 3.2 Toxicogenomics; 3.2.1 Profiling Gene Expression; 3.2.2 Pathway Arrays; 3.2.3 Comparative Evaluation of Immunotoxicants; 3.2.4 miRNA and siRNA, Gene Expression Regulators; 3.2.5 mRNA Splicing; 3.2.6 RNA-Seq; 3.2.7 Proteomics; 3.2.8 Molecular Genomics; 3.2.9 Phenotypic Anchoring, Dose Response, Time Course; 3.3 Bioinformatics and Data Analysis; 3.3.1 Effect Markers and Machine Learning.
  table of contents: 3.4 Multiple Omic Approaches in the Evaluation of Immunosuppressive Compounds3.4.1 Multiple Omic Approaches in the Study of Hypersensitivity; 3.5 Summary and Conclusions; References; Chapter 4 Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins; 4.1 Introduction; 4.2 The AOP for Skin Sensitization; 4.3 The Molecular Processes in the MOA for Sensitization Induction; 4.3.1 Bioavailability: the Compound Acquires Access to the System.
  table of contents: 4.3.4 Dendritic Cell Activation: from Innate Responses to DC Maturation4.3.5 Dendritic Cell Migration: Translating the Message into Specific Actions; 4.3.6 T-Cell Priming and Proliferation: the Turning-Point between Sensitization and Effect; 4.4 Summary; References; Chapter 5 Chemical Allergen-Induced Skin Cell Activation; 5.1 Introduction; 5.2 Breaching the Barriers; 5.3 Role of the Extracellular Matrix in Skin Inflammation; 5.4 Cytoprotective Responses and Skin Inflammation; 5.5 Skin Dendritic Cells -- Tolerance versus Immunity; 5.6 DC Activation and Migration; 5.7 The Role of Danger Signals.
  note: edited by Emanuela Corsini and Henk van Loveren.
  note: Includes bibliographical references and index.
  subject:
    topic: Immunotoxicology
  subject:
    topic: Immunotoxins
    topic: adverse effects
  subject:
    topic: Immune System Diseases
    topic: chemically induced
  classification: RC108 .M65 2014
  classification: 616.044 616/.044
  classification: QW 630.5.I3
  identifier: 9783527676972
  identifier: 352767697X
  identifier: 9783527676965
  identifier: 3527676961
  identifier: 1322007438
  identifier: 9781322007434
  identifier: 9783527335190
  identifier: 3527335196
  identifier: 9783527676996
  identifier: 3527676996
  identifier: 9783527676989
  identifier: 3527676988
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: NhCcYBP
    record creation date: 140801
    record change date: 20260214210555.1
    record identifier: in00004675601
    language of cataloging:
      language term: eng