Structure-based design of drugs and other bioactive molecules : tools and strategies /

Bibliographic Details
Main Authors:	Ghosh, Arun K., Prof. Dr (Author), Gemma, Sandra (Author)
Format:	eBook
Language:	English
Published:	Weinheim : Wiley-VCH, [2014]
Subjects:	Drug development. Bioactive compounds. Biopolymers. Ligand binding (Biochemistry) Protease inhibitors. Drugs > Structure-activity relationships. Drugs > Design. Molecular structure. Structure-activity relationships (Biochemistry) Drug Design Molecular Structure Biopolymers > chemistry Protease Inhibitors > chemistry Structure-Activity Relationship Biopolymers
Online Access:	Connect to the full text of this electronic book

Table of Contents:

1. From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design
Part One Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors
2. Design of Inhibitors of Aspartic Acid Proteases
3. Design of Serine Protease Inhibitors
4. Design of Proteasome Inhibitors
5. Design of Cysteine Protease Inhibitors
6. Design of Metalloprotease Inhibitors
7. Structure-Based Design of Protein Kinase Inhibitors
8. Protein X-Ray Crystallography in Structure-Based Drug Design
9. Structure-Based Design Strategies for Targeting G-Protein-Coupled Receptors (GPCRs)
Part Two Structure-Based Design of FDA-Approved Inhibitor Drugs and Drugs Undergoing Clinical Development
10. Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertension: Design and Discovery of Captopril.
11. HIV-1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, Indinavir, and Darunavir
12. Protein Kinase Inhibitor Drugs for Targeted Cancer Therapy: Design and Discovery of Imatinib, Nilotinib, Bafetinib, and Dasatinib
13. NS3/4A Serine Protease Inhibitors for the Treatment of HCV: Design and Discovery of Boceprevir and Telaprevir
14. Proteasome Inhibitors for the Treatment of Relapsed Multiple Myeloma: Design and Discovery of Bortezomib and Carfilzomib
15. Development of Direct Thrombin Inhibitor, Dabigatran Etexilate, as an Anticoagulant Drug
16. Non-Nucleoside HIV Reverse Transcriptase Inhibitors for the Treatment of HIV/AIDS: Design and Development of Etravirine and Rilpivirine
17. Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren
18. Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir
19. Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma: Design and Discovery of Dorzolamide
20 B-Secretase Inhibitors for the Treatment of Alzheimer's Disease: Preclinical and Clinical Inhibitors.