http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Structure-based design of drugs and other bioactive molecules
1 online resource (xv, 458 pages : : illustrations.)
1. From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design -- Part One Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors -- 2. Design of Inhibitors of Aspartic Acid Proteases -- 3. Design of Serine Protease Inhibitors -- 4. Design of Proteasome Inhibitors -- 5. Design of Cysteine Protease Inhibitors -- 6. Design of Metalloprotease Inhibitors -- 7. Structure-Based Design of Protein Kinase Inhibitors -- 8. Protein X-Ray Crystallography in Structure-Based Drug Design -- 9. Structure-Based Design Strategies for Targeting G-Protein-Coupled Receptors (GPCRs) -- Part Two Structure-Based Design of FDA-Approved Inhibitor Drugs and Drugs Undergoing Clinical Development -- 10. Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertension: Design and Discovery of Captopril.
11. HIV-1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, Indinavir, and Darunavir -- 12. Protein Kinase Inhibitor Drugs for Targeted Cancer Therapy: Design and Discovery of Imatinib, Nilotinib, Bafetinib, and Dasatinib -- 13. NS3/4A Serine Protease Inhibitors for the Treatment of HCV: Design and Discovery of Boceprevir and Telaprevir -- 14. Proteasome Inhibitors for the Treatment of Relapsed Multiple Myeloma: Design and Discovery of Bortezomib and Carfilzomib -- 15. Development of Direct Thrombin Inhibitor, Dabigatran Etexilate, as an Anticoagulant Drug -- 16. Non-Nucleoside HIV Reverse Transcriptase Inhibitors for the Treatment of HIV/AIDS: Design and Development of Etravirine and Rilpivirine -- 17. Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren -- 18. Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir -- 19. Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma: Design and Discovery of Dorzolamide -- 20 B-Secretase Inhibitors for the Treatment of Alzheimer's Disease: Preclinical and Clinical Inhibitors.
Includes bibliographical references and index.
Structure-activity relationships (Biochemistry)