http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
design, operation and novel applications
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries.
Title Page -- Copyright -- Table of Contents -- Preface -- List of Contributors -- Chapter 1: Challenges for Bioreactor Design and Operation -- 1.1 Introduction -- 1.2 Biotechnology Milestones with Implications on Bioreactor Design -- 1.3 General Features of Bioreactor Design -- 1.4 Recent Trends in Designing and Operating Bioreactors -- 1.5 The Systems Biology Approach -- 1.6 Using Conceptual Design Methodology -- 1.7 An Outlook on Challenges for Bioreactor Design and Operation -- References -- Chapter 2: Design and Operation of Microbioreactor Systems for Screening and Process Development.
2.1 Introduction -- 2.2 Key Engineering Parameters and Properties in Microbioreactor Design and Operation -- 2.3 Design of Novel Stirred and Bubble Aerated Microbioreactors -- 2.4 Robotics for Microbioreactors -- 2.5 Fed-Batch and Continuous Operation of Microbioreactors -- 2.6 Monitoring and Control of Microbioreactors -- 2.7 Conclusion -- References -- Chapter 3: Bioreactors on a Chip -- 3.1 Introduction -- 3.2 Advantages of Microsystems -- 3.3 Scaling Down the Bioreactor to the Microfluidic Format -- 3.4 Microfabrication Methods for Bioreactors-On-A-Chip -- 3.5 Fabrication Materials.
3.6 Integrated Sensors for Key Bioreactor Parameters -- 3.7 Model Organisms Applied to BRoCs -- 3.8 Applications of Microfluidic Bioreactor Chip -- 3.9 Scale Up -- 3.10 Conclusion -- References -- Chapter 4: Scalable Manufacture for Cell Therapy Needs -- 4.1 Introduction -- 4.2 Requirements for Cell Therapy -- 4.3 Stem Cell Types and Products -- 4.4 Paradigms in Cell Therapy Manufacture -- 4.5 Cell Therapy Manufacturing Platforms -- 4.6 Microcarriers and Stirred-Tank Bioreactors -- 4.7 Future Trends for Microcarrier Culture -- 4.8 Preservation of Cell Therapy Products -- 4.9 Conclusions.
6.2 Culture Technologies for Pluripotent Stem Cell Expansion -- 6.3 3D Suspension Culture -- 6.4 Autologous Versus Allogeneic Cell Therapies: Practical and Economic Considerations for hPSC Processing -- 6.5 Upscaling hPSC Cardiomyogenic Differentiation in Bioreactors -- 6.6 Conclusion -- References -- Chapter 7: Culturing Entrapped Stem Cells in Continuous Bioreactors -- 7.1 Introduction -- 7.2 Materials Used in Stem Cell Entrapment -- 7.3 Synthetic Materials -- 7.4 Natural Materials -- 7.5 Manufacturing and Regulatory Constraints -- 7.6 Mass Transfer in the Entrapment Material.
Includes bibliographical references and index.