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Tumor Suppressor Par-4 : Role in Cancer and Other Diseases /

Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Rangnekar, Vivek M. (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2021.
Edition:1st ed. 2021.
Subjects:
Medicine-Research.
Biology-Research.
Internal medicine.
Biomedical Research.
Internal Medicine.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Introduction.
  • Part 1
  • Chapter 1. Role of Par-4 in lung cancer
  • Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma
  • Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers
  • Chapter 4. Regulation of Par-4 and role in GI tumors
  • Chapter 5. Role of Par-4 in prostate cancer
  • Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer
  • Chapter 7. Role of Par-4 and GRP78 in Glioblastoma
  • Chapter 8. Role of Par-4 in breast cancer recurrence
  • Chapter 9. Involvement of Par-4 in breast cancer
  • Chapter 10. Role of endogenous Par-4 in CLL
  • Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth
  • Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells
  • Chapter 13. Par-4 expression in cholangiocarcinoma
  • Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells
  • Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target
  • Chapter 16. Par-4 cleavage is required for TNF induced apoptosis
  • Chapter 17. Par-4 secretagogues
  • Chapter 18. Recombinant production and characterization of SAC
  • Chapter 19. Anti-tumor effects of plant derived Par-4
  • Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages
  • Part 2 - Role in other Diseases
  • Chapter 21. Role of Par-4 in ceramide inducible effects in neurons
  • Chapter 22. Role of Par-4 in Alzheimers disease
  • Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression
  • Chapter 24. Par-4 (PAWR) in major depressive disorder
  • Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes
  • Chapter 26. Par-4 in cardiac fibroblast senescence
  • Chapter 27. Par-4 in ocular development and disease
  • Chapter 28. Par-4 in apoptosis during human salivary gland development
  • Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis
  • Chapter 30. Lessons from knockout mice
  • Part 3 - From Bench to Bedside
  • Chapter 31. Par-4 secretagogues in clinical trials
  • Chapter 32. Potential of Par-4 as a therapeutic target for cancer.