Ketoconazole : oral absorption, serum clearance, and tissue distribution in the dog : a thesis /
ABSTRACT: The serum half-time of ketoconazole was measured in 4 normal dogs after a single intravenous dosage (30 mg/kg) and the average half-time was 4.9 ± 1.4 hrs (means ± sd). The magnitude and time of maximum serum concentration of ketoconazole in 5 normal dogs was measured after a single dosage...
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| Format: | Thesis Book |
| Language: | English |
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| Summary: | ABSTRACT: The serum half-time of ketoconazole was measured in 4 normal dogs after a single intravenous dosage (30 mg/kg) and the average half-time was 4.9 ± 1.4 hrs (means ± sd). The magnitude and time of maximum serum concentration of ketoconazole in 5 normal dogs was measured after a single dosage (30 mg/kg) given orally. Maximum absorption occurred 2.7 ± 1.6 hrs following administration and the maximum serum concentration obtained was 11.5 ± 1.6 ug/ml. Ketoconazole concentrations were measured in various tissues and body fluids of dogs given 3 different dosages of ketoconazole. The dosages used were 15, 30, and 60 mg/kg given orally once daily for 8 days. Concentrations of ketoconazole above the minimal inhibitory concentration (MIC) required by most susceptible mycotic infections were present in all tissues and body fluids with the exception of bone and skin (15 mg/kg dosage). |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Veterinary Medicine and Surgery." "Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of Master of Science May 1983." Approved as to style and content by: David K. Chester, George E. Lees, Dan Hightower, Robert F. Playter. |
| Physical Description: | vii, 41 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references (leaves 29-32). |