Cover Image

Bayesian designs for phase I-II clinical trials /

Bibliographic Details
Main Authors: Yuan, Ying (Professor of biostatistics), Nguyen, Hoang Q. (Author), Thall, Peter F. (Author)
Corporate Author: ProQuest (Firm)
Format: eBook
Language:English
Published: Boca Raton : CRC Press, 2016.
Series:Chapman & Hall/CRC biostatistics series.
Subjects:
Clinical trials > Statistical methods.
Drugs > Testing > Statistical methods.
Bayesian statistical decision theory.
Clinical Trials, Phase I as Topic.
Clinical Trials, Phase II as Topic.
Statistics as Topic.
Bayes Theorem.
Dose-Response Relationship, Drug.
Ebooks.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Why conduct phase I-II trials?
  • The phase I-II paradigm
  • Establishing priors
  • Efficacy : toxicity trade-off-based designs
  • Designs with late-onset outcomes
  • Utility-based designs
  • Personalized dose finding
  • Combination trials
  • Optimizing molecularly targeted agents
  • Optimizing doses in two cycles
  • Optimizing dose and schedule
  • Dealing with dropouts
  • Optimizing intra-arterial tPA
  • Optimizing sedative dose in preterm infants.