Clinical research for surgeons /
Clinical Research for Surgeons is a practical guide for understanding, planning, conducting, and evaluating surgical research. It covers the principles of evidence-based surgery and applies these principles to the design of suitable research studies. The reader will come to fully understand importan...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Stuttgart ; New York :
Thieme,
[2009]
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book. |
Table of Contents:
- Why we need clinical research
- Historical perspectives of clinical research
- Evidence-based surgery defined
- Myths and misconceptions about evidence-based medicine
- Becoming an evidence-based surgeon
- Principles of clinical research
- Various research design classifications
- Hierarchy of research studies: from case series to meta-analyses
- Randomized and nonrandomized studies
- Understanding research study design
- Clinical case series
- Case-control study
- Prospective cohort study
- Randomized trial
- Meta-analysis
- Economic analysis
- Diagnostic study
- Reliability study
- Understanding outcomes measurement
- Classification of outcomes
- What makes an outcome measure useful
- Common generic outcome scales for surgeons
- Common disease-specific outcome scales for surgeons
- Understanding treatment effects
- Common ways to present treatment effects
- Confidence interval defined
- P value defined
- Errors in hypothesis testing
- Clinical versus statistical significance
- Practice of clinical research
- Planning a research study
- Requirements of a clinical research proposal
- Identification of a good research question
- How to conduct a comprehensive literature search
- Guide to planning a randomized trial
- Guide to planning a nonrandomized study
- Study sample size
- How to budget for a research study
- Research ethics, review boards, and consent forms
- Regulatory issues in the evaluation of a new device or drug
- Strategies in research funding
- Conducting a research study
- Roles of the research team
- Role of a central methods center
- Role of a data monitoring committee
- Need for separate adjudication of outcomes
- Data management
- Study case report forms
- Study manual of operations
- Review of basic statistical principles
- Statistical means and proportions
- Regression analysis
- Analysis of variance
- Correlation defined.