A sequential study of the pathogenesis of disease caused by Trypanosoma vivax in experimentally infected calves, utilizing clinical, pathological, histopathological and immunofluorescent techniques : a thesis /
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| Format: | Thesis Book |
| Language: | English |
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[College Station, Tex.] :
[Texas A&M University],
[1971]
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| Subjects: |
| Abstract: | ABSTRACT: Tryanosoma vivax obtained from a clinically sick cow near Neiva, Colombia, was passed in a sheep and a calf and inoculated into the jugular vein of 14 Holstein-Friesian calves. Fever occurred by 24 hours. It was estimated that practically all of the 14 calves would have died spontaneously with the first and subsequent parasitemias were decreases in hemoglobin, PCV, M:E ratio, serum albumin, A:G ratio and neutropenia. All calves exhibited gradual weight loss by 2 weeks and later submandibular edema usually became evident. Consistent post mortem lesions seen after 4 weeks were conspicuously hypertrophied, edematous lymph nodes, hypertrophied hemal lymph nodes, emaciation, rounded right heart, palpably firm liver, atrophied thymus and hypertrophied femoral bone marrow. Associated with T. vivax of the infecting inoculum and succeeding parasitemias were generalized endothelial hypertrophy and mononuclear cell infiltration along blood and lymphvessels with proteinuria and bone marrow hyperplasia. Generalized lymphatic and RE hyperplasia occurred, but was not proven to be due to the trypanosomiasis. At 3 weeks there was aggregations of macrophages containing engulfed material distributed along capillaries in pulmonary interalveolar tissue, and this lesion in combination with the anemia and apparent cardiac insufficiency were thought important in the development of anoxia, and probably contributed to the single fatality observed. Pariacinar congestiona and fatty metamorphosis of midzonal hepatocytes were probably related to the failing heart and indirectly to the pulmonary lesion. Cystitis and pyelonephritis in the last 2 calves to be killed probably was a reflection of generalized, chronic debility. The detection of trypanosomes in histologic sections, using a direct fluorescent antibody technique, was impeded by a generalized fluorescence of tissues was related to the presence of soluble antigens which are known to exist in T. vivax infections. |
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| Item Description: | Vita. "Major Subject: Veterinary Pathology". "Submitted to the Graduate College of the Texas A&M University in partial fulfillment of the requirements for the degree of Master of Science May 1971". |
| Physical Description: | viii, 61 leaves : illustrations ; 28 cm |
| Bibliography: | Includes bibliographical references. |