Some observations and physiologic effects of adrenalectomy in the dog : a thesis by /
ABSTRACT: Bilaterally adrenalectomized dogs were studied to identify and quantitate changes in plasma concentrations of sodium and potassium, in the electrocardiogram (ECG), and in physical state. Results were analyzed to evaluate relationships present among the observed changes. The five day peri...
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| Format: | Thesis Book |
| Language: | English |
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College Station, TX :
Texas A&M University,
1970.
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| Summary: | ABSTRACT: Bilaterally adrenalectomized dogs were studied to identify and quantitate changes in plasma concentrations of sodium and potassium, in the electrocardiogram (ECG), and in physical state. Results were analyzed to evaluate relationships present among the observed changes. The five day period immediately prior to death was selected as the post-operative evaluation period. During this period plasma sodium concentration decreased and plasma potassium concentrations increased significantly. Principal changes observed in the ECG were in T wave configuration, QRS interval and heart rate. T waves became peaked in appearance, QRS intervals increased, and tachycardia developed which persisted until the day of death, when terminal bradycardia supervened. P wave amplitude and Q-Tc interval displayed little change until the day of death, when P waves decreased in height and Q-Tc intervals shortened. A decrease in arterial blood pH during the observation period indicated development of a metabolic acidosis. Findings of the study suggest that several of the parameters measured would have possible diagnostic value in identifying and assessing advanced adrenocortical hypofunction. Those indicated to be more reliable are plasma concentrations of sodium and potassium, T wave configuration, and QRS interval. Their use in evaluating animals displaying general signs of adrenocortical failure could provide means for distinguishing adrenal failure from clinically similar conditions. |
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| Item Description: | "Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of Master of Science May 1970". "Major Subject: Veterinary Physiology". Approved as to style and content by: J. D. McCrady, R. H. Davis, D. R. Clark, E. W. Ellett Vita. |
| Physical Description: | ix, 54 leaves : illustrations, photograph ; 28 cm |
| Bibliography: | Includes bibliographical references (leaves 30-34). |