Role of periostin in the formation and growth of polyps in Apc[min/+] mice : a thesis /
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| Format: | Thesis Book |
| Language: | English |
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[College Station, Tex.] :
[Texas A&M University System Health Science Center],
[2011]
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| Subjects: |
| Abstract: | ABSTRACT: Periostin is an extracellular matrix protein that binds the [alpha]v[beta]₃ and [alpha]v[beta]₅ integrins, and activates focal adhesion kinase (FAK) and Akt. Periostin plays a significant role in tumor growth by promoting angiogenesis and preventing apoptosis during cancer progression. Therefore, we hypothesized that periostin loss would have a beneficial effect on survival and prevent tumor growth in colorectal cancer. To test our hypothesis, we investigated the effect periostin loss had on tumor growth and survival in Apc[min/+] mice, a mouse model for colorectal cancer. Our studies demonstrate that loss of periostin in Apc[min/+] mice results in a marked decrease in the number of intestinal polyps and an increase in animal survival. Additionally, the periostin loss results in a decrease in cell proliferation and an increase in apoptosis. These data indicate that periostin promotes tumor formation and progession, and is a potential drug target for clinical treatments of cancer. |
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| Item Description: | Vita. "Major Subject: Medical Sciences". "Submitted to the Office of Research and Graduate Studies of The Texas A&M University System Health Science Center in partial fulfillment of the requirements for the degree of Master of Science December 2011." Approved as to style and content by: Troy A. Baudino, Brett M. Mitchell, David E. Dostal, Alejandro C. Arroliga |
| Physical Description: | xiii, 93 leaves : illustrations (mostly color) ; 28 cm. |
| Bibliography: | Includes bibliographical references (leaves 82-91). |