Thiacetarsamide therapy of heartworm disease in cats : a pharmacokinetic study : a thesis /
ABSTRACT: The pharmacokinetic values were determined for thiacetarsamide in 14 healthy cats. The clinical, laboratory, and pathological features of thiacetarsamide-treated cats were characterized for up to 14 days following drug administration. Cats were given rapid intravenous bolus injections of...
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
College Station, TX :
Texas A&M University,
1988.
|
| Subjects: |
| Summary: | ABSTRACT: The pharmacokinetic values were determined for thiacetarsamide in 14 healthy cats. The clinical, laboratory, and pathological features of thiacetarsamide-treated cats were characterized for up to 14 days following drug administration. Cats were given rapid intravenous bolus injections of thiacetarsamide every 12 hours for a total of 4 doses. Blood specimens were obtained 0, 4, 6, 10, 15, 30, 45, and 60 minutes, and 2, 3, 5, 8, and 12 hours after the first thiacetarsamide injections, and at the same time intervals after the fourth injection. Total blood arsenic concentrations were deterimined by an atomic absorption assay, and kinetic values were derived. Cats treated with thiacetarsamide had a high incidence of depression, anorexia, nausea, and emesis after each dose. Increased respiratory effort and excessive bronchovesicular sounds were noted in at least 40 percent of the treated animals. An idiopathic acute respiratory distress syndrome occurred in 3 of the treated cats, causing fulminant pulmonary edema, respiratory failure, and death within 1 to 3 hours after the second dose of thiacetarsamide. Administration of thiacetarsamide was associated with an elevation of hepatic leakage enzymes and a mild hyperphosphatemia. Microscopic changes observed at postmortem examination included acute and chronic alveolar and peribronchiolar edema, emphysema and interstitial pneumonitis. Hepatic lesions were common and included hepatocellular hydropic degeneration and edema. The single-dose and multiple-dose pharmacokinetic values fit a two-compartment open model. There was a high degree of variation between individual animals during both the single-dose and the multiple-dose studies. There was a significant (P<0.05) difference between the pharmacokinetics over multiple-dose intervals. It was concluded that thiacetarsamide usage at 2.2 mg per kg every 12 hours for 4 doses may not be safe for cats. Further pharmacokinetic and efficacy studies of thiacetarsamide in heartworm-infected cats should elucidate optimum dosage schedules. |
|---|---|
| Item Description: | Typescript (photocopy). "Submitted to the Office of Graduate Studies Texas A&M University in partial fulfillment of the requirements for the degree of Master of Science August 1988". "Major Subject: Veterinary Medicine and Surgery". Approved as to style and content: George E. Lees, Scott A. Brown, Kenneth W. Knauer, John R. August. Vita. |
| Physical Description: | xii, 85 leaves : ills. ; 29 cm. |
| Bibliography: | Includes bibliographical references (leaves 76-79). |