The use of mannitol and/or sodium bicarbonate in the prevention of amphotericin B induced nephrotoxicity : a thesis /
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| Format: | Thesis Book |
| Language: | English |
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College Station, TX :
Texas A&M University,
1982.
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| Abstract: | ABSTRACT: The effects of amphotericin B administration upon renal function, serum electrolytes and arterial blood gases were studied in 4 groups of dogs. Nephrotoxicity was induced in all groups of animals, to varying degrees. The nephrotoxicity was characterized by decreases in glomerular filtration rates, maximum urinary concentrating ability, urinary acidification abnormalities and azotemia. Adjuvant therapy consisting of mannitol, sodium bicarbonate and mannitol-sodium bicarbonate combinations was used to modify the nephrotoxic effect of amphotericin B. Mannitol and mannitol-sodium bicarbonate proved beneficial in alleviating decreases in glomerular filtration rates (P0.001) and maximum urinary concentrating ability (P<0.05). Serum creatinine retention was also significantly less in these treatment groups (P<0.001). All groups of animals had partial distal tubular dysfunction which was demostrated by acid loading tests. Significant changes were not found for concentrations of serum sodium, potassium, or bicarbonate, or for arterial pH. It is therefore recommended that mannitol or mannitol-sodium bicarbonate be used in the prevention of amphotericin B nephrotoxicity. |
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| Item Description: | Vita. "Major Subject: Veterinary Medicine and Surgery". "Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of Master of Science December 1982." Approved as to style and content by: Kenneth W. Knauer, Robert F. Playter, D. R. Clark, David Chester. |
| Physical Description: | xiii, 159 leaves : illustrations ; 28 cm. |
| Bibliography: | Includes bibliographical references (leaves 73-77). |