The efficacy of single-dose and three-day antibiotic therapy in experimentally induced Escherichia coli urinary tract infections in dogs : a thesis /
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| Format: | Thesis Book |
| Language: | English |
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[College Station, Tex.] :
[Texas A&M University],
[1986]
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| Subjects: |
| Abstract: | ABSTRACT: This study determined the efficacy of single-dose and three-day therapeutic regimens for eradication of experimentally induced Escherichia coli urinary tract infections in dogs. Comparisons were made between the responses obtained in male and female dogs and between the responses obtained using 2 different antimicrobial agents (amikacin and trimethoprim-sulfadiazine). Experimental groups contained equal numbers of males and females. In the first experiment, hemolytic E. coli urinary bladder infections were induced in 12 dogs. Four dogs (Group 1) were treated with a single dose of amikacin, 4 dogs (Group 2) received a single dose of trimethoprim-sulfadiazine, and 4 dogs (Group 3) remained untreated. Complete urinalyses and quantitative urine cultures were performed immediately before treatment, 48 hours posttherapy, and 14 days posttherapy. In the second experiment, there were 2 phases. In phase A, E. coli urinary bladder infections were induced in 12 new dogs. Four dogs (Group 1) were treated twice daily for 3 days with amikacin, 4 dogs (Group 2) were treated twice daily for 3 days with trimethoprim-sulfadiazine, and 4 dogs (Group 3) remained untreated. In phase B, the untreated control dogs from experiments I and II were utilized for trials of three-day therapy. Four dogs (Group 4) were treated twice daily for 3 days with amikacin, and 4 dogs (Group 5) were treated twice daily for 3 days with trimehoprim-sulfadiazine. Complete urinalyses and quantitative urine cultures were performed immediately before therapy, 48 hours after the completion of therapy, and 14 days after the initiation of therapy. This study demonstrated that single-dose therapy was not effective in this experimental model. Three-day therapy was not effective in males regardless of the antimicrobial agent used or in females whem amikacin was utilized. Results of routine urinalyses were not reliable for predicting the presence or absence of urinary tract infection. |
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| Item Description: | Vita. "Major Subject: Veterinary Medicine and Surgery". "Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of Master of Science May 1986." Approved as to style and content by: George E. Lees, Russell B. Simpson, Sandee M. Hartsfield, Kenneth W. Knauer. |
| Physical Description: | xiii, 201 leaves : illustrations ; 28 cm. |
| Bibliography: | Includes bibliographical references (leaves 40-43). |