Autocrine regulation of cholangiocarcinoma growth by histamine synthesis and histamine receptor interaction : a dissertation /
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| Format: | Thesis Book |
| Language: | English |
| Published: |
[College Station, Tex.] :
[Texas A&M University System Health Science Center],
[2010]
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| Subjects: |
| Abstract: | ABSTRACT: Histamine has played a historic role in inflammatory disease processes. Studies of the synthesis of histamine, along with histamine receptors, have shown the various effects on different pathologies. In this study we investigated the role of histamine and histamine receptors on a deadly biliary cancer termed cholangiocarcinoma. This cancer is difficult to diagnose and generally not responsive to traditional cancer treatments. Understanding the mechanisms that regulate cholangiocarcinoma growth is imperative to finding successgul treatment regimens. Using in vitro and in vivo experimental techniques we found that the enzymes responsible for histamine synthesis are dysregulated, causing an increase in tumor growth. Further, the histamine receptors are able to differentially regulate cholangiocarcinoma growth. Histamine was found to behave as a trophic factor increasing tumor growth, angiogenic potential and mast cell presence. Blocking histamine synthesis ablates these processes and may prove to be an important therapeutic tool in the treatment of cholangiocarcinoma. |
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| Item Description: | Vita. "Major Subject: Medical Sciences". "Submitted to the Office of Research and Graduate Studies of The Texas A&M Health Science Center Graduate School of Biomedical Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy December 2010." Approved as to style and content by: Gianfranco D. Alpini, Cynthia J. Meininger, Sharon DeMorrow, John Greene, Alejandro Arroliga. |
| Physical Description: | xiii, 114 leaves : illustrations ; 28 cm. |
| Bibliography: | Includes bibliographical references (leaves 91-113). |