Enzyme inhibition in drug discovery and development : the good and the bad /

Bibliographic Details
Other Authors:	Lu, Chuang, Li, A. P.
Format:	Book
Language:	English
Published:	Hoboken, N.J. : Wiley, [2010]
Subjects:	Enzyme inhibitors. Drug development. Drugs > Metabolism. Enzyme Inhibitors > pharmacology. Drug Discovery > methods. Enzyme Inhibitors > chemical synthesis.

Table of Contents:

The drug discovery process
Medicinal chemistry of the optimization of enzyme inhibitors
Bioanalytical technologies in drug discovery
Safety biomarkers in drug development : emerging trends and implications
The role of drug metabolism in drug discovery
Applied pharmacokinetics in drug discovery and development
Enzyme inhibition and inactivation : cytochrome P450 enzymes
Cytochrome P450 induction
Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction
Enzyme inhibition in various in vitro systems
Cytochrome P450 degradation and its clinical relevance
Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition
Evaluation of inhibitors of drug metabolism in human hepatocytes
Grapefruit juice and its constituents as new esterase inhibitors
Transporter-xenobiotic interactions : an important aspect of drug development studies
Polymorphisms of drug transporters and their clinical implications
Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation
Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach
NF-kB : mechanism, tumor biology, and inhibitors
G-protein-coupled receptors as drug targets
Pharmacological modulation of ion channels for the treatment of chronic pain
Targeting the mTOR pathway for tumor therapeutics
HIV-1 protease inhibitors as antiretroviral agents