rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Enzyme inhibition in drug discovery and development
    sub title: the good and the bad
  name:
    name part: Lu, Chuang.
  name:
    name part: Li, A. P.
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: nju
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiii, 854 pages, 8 unnumbered pages of plates : illustrations (some color) ; 25 cm.
  table of contents: The drug discovery process -- Medicinal chemistry of the optimization of enzyme inhibitors -- Bioanalytical technologies in drug discovery -- Safety biomarkers in drug development : emerging trends and implications -- The role of drug metabolism in drug discovery -- Applied pharmacokinetics in drug discovery and development -- Enzyme inhibition and inactivation : cytochrome P450 enzymes -- Cytochrome P450 induction -- Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction -- Enzyme inhibition in various in vitro systems -- Cytochrome P450 degradation and its clinical relevance -- Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition
  table of contents: Evaluation of inhibitors of drug metabolism in human hepatocytes -- Grapefruit juice and its constituents as new esterase inhibitors -- Transporter-xenobiotic interactions : an important aspect of drug development studies -- Polymorphisms of drug transporters and their clinical implications -- Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation -- Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach -- NF-kB : mechanism, tumor biology, and inhibitors -- G-protein-coupled receptors as drug targets -- Pharmacological modulation of ion channels for the treatment of chronic pain -- Targeting the mTOR pathway for tumor therapeutics -- HIV-1 protease inhibitors as antiretroviral agents
  note: edited by Chuang Lu, Albert P. Li.
  note: Includes bibliographical references and index.
  subject:
    topic: Enzyme inhibitors
  subject:
    topic: Drug development
  subject:
    topic: Drugs
    topic: Metabolism
  subject:
    topic: Enzyme Inhibitors
    topic: pharmacology
  subject:
    topic: Drug Discovery
    topic: methods
  subject:
    topic: Enzyme Inhibitors
    topic: chemical synthesis
  classification: QP601.5 .E58 2010
  classification: 615/.19
  classification: QU 143 E605 2010
  classification: QU 143 E619 2010
  identifier: 9780470281741 (cloth)
  identifier: 047028174X (cloth)
  identifier: 2009014027
  record info:
    record content source: DNLM/DLC
    record creation date: 090401
    record change date: 20191204153636.0
    record identifier: in00004513618