Predictive toxicology in drug safety /
"According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), "developing new scientific approaches to detecting, understanding, predicting, and preventing adverse events" was a critical path to the future of drug safety. This book brings together a collec...
| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
Cambridge ; New York :
Cambridge University Press,
2011.
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| Subjects: |
Table of Contents:
- The human predictive value of combined animal toxicity testing : current state and emerging approaches
- Screening approaches for genetic toxicity
- Cardiac safety
- Predicting drug-induced liver injury : safer patients or safer drugs?
- In vitro evaluation of metabolic drug-drug interactions
- Reliability of reactive metabolite and covalent binding assessments in prediction of idiosyncratic drug toxicity
- Immunotoxicology of haptens and nucleic acids
- Predictive models for neurotoxicity assessment
- De-risking developmental toxicity-mediated drug attrition in the pharmaceutical industry
- Integrated approaches to lead optimization : improving the therapeutic index
- Predictive toxicology approaches for oncology drugs
- Mechanism-based toxicity studies for drug development
- Fish embryos as alternative models for drug safety evaluation
- The role of genetic-modified mouse models in predictive toxicology
- Toxicogenomic and pathway analysis
- Drug safety biomarkers
- Application of TK/PD modeling in predicting dose-limiting toxicity
- Prediction of therapeutic index of antibody-based therapeutics : mathematical modeling approaches
- Vaccine toxicology : non-clinical predictive strategies