Untangling the double helix : DNA entanglement and the action of the DNA topoisomerases /
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| Format: | Book |
| Language: | English |
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Cold Spring Harbor, N.Y. :
Cold Spring Harbor Laboratory Press,
[2009]
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| Subjects: |
Table of Contents:
- An insuperable problem
- Nature's solutions : the DNA topoisomerases
- Breaking a DNA strand and holding onto
- The broken ends
- A magic swivel
- Moving one DNA double helix through another
- Real-time viewing of the DNA topoisomerases in action
- Manifestations of DNA entanglement: replication and recombination
- Manifestations of DNA entanglement : transcription and gene expression
- Beyond DNA untanglement: new twists on an old
- Theme
- From nature's battlefields to the clinical wards
- Appendix 1 : identification of the covalent intermediates in topoisomerase-catalyzed reactions
- Appendix 2 catalysis of dna breakage and rejoining by dna topoisomerases.