Lipoic acid : energy production, antioxidant activity and health effects /

Bibliographic Details
Other Authors: Patel, Mulchand S., Packer, Lester
Format: Book
Language:English
Published: Boca Raton : CRC Press, [2008]
Series:Oxidative stress and disease ; 24.
Subjects:
Table of Contents:
  • A trail of research on lipoic acid
  • Lipoic acid biosynthesis
  • The search for potent alpha-lipoic acid derivatives : chemical and pharmacological aspects
  • Novel indole lipoic acid derivatives : synthesis and their antioxidant effects
  • Alpha-keto acid dehydrogenase complexes and glycine cleavage system : their regulation and involvement in pathways of carbohydrate, protein, and fat metabolism
  • Pyruvate dehydrogenase complex regulation and lipoic acid
  • Role of lipoyl domains in the function and regulation of the mammalian pyruvate dehydrogenase complex
  • -- Inactivation and inhibition of alpha-ketoglutarate dehydrogenase : oxidative modification of lipoic acid
  • Lipoate-protein ligase A : structure and function
  • An evaluation of the stability and pharmacokinetics of R-lipoic acid and R-dihydrolipoic acid dosage forms in human plasma from healthy subjects
  • Pharmacokinetics, metabolism, and renal excretion of alpha-lipoic acid and its main metabolites in humans
  • Modulation of cellular redox and metabolic status by lipoic acid
  • Redoxin connection of lipoic acid
  • Lipoic acid as an inducer of phase II detoxification enzymes through activation of Nrf2-dependent gene expression
  • -- Deficiency disorders of components of PDH complex : E2, E3, and E3BP deficiencies
  • Relationship between primary biliary cirrhosis and lipoic acid
  • Effects of lipoic acid on insulin action in animal models of insulin resistance
  • Activation of cytoprotective signaling pathways by alpha-lipoic acid
  • Selenotrisulfide derivatives of alpha-lipoic acid : potential use as a novel topical antioxidant
  • Alpha-lipoic acid : a potent mitochondrial nutrient for improving memory deficit, oxidative stress, and mitochondrial dysfunction
  • Effects of alpha-lipoic acid on AMP-activated protein kinase in different tissues : therapeutic implications for the metabolic syndrome.