Genomics and pharmacogenomics in anticancer drug development and clinical response /
| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
Totowa, N.J. :
Humana Press,
[2008]
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| Series: | Cancer drug discovery and development.
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| Subjects: |
Table of Contents:
- Toward the realization of the promise of microarrays in oncology
- Cell-based models to identify genetic variants contributing to anticancer drug response
- Proteomic analysis in cancer patients
- MicroRNAs and discovery of new targets
- Pharmacogenomics of the National Cancer Institute's 60-tumor cell panel
- Use of single-nucleotide polymorphism array for tumor aberrations in gene copy numbers
- Concordance between tumor and germline DNA
- Epidermal growth factor receptor mutations and sensitivity to selective kinase inhibitors in human lung cancer
- BCR-ABL mutations and imatinib resistance in chronic myeloid leukemia patients
- Role of thymidylate synthase gene variations in colorectal cancer patients
- Thiopurines in the treatment of childhood acute lymphoblastic leukemia and genetic variants of the thiopurine S-Methyltransferase gene
- Impact of polymorphisms on the clinical outcomes of monoclonal antibody therapy against hematologic malignancies
- DNA repair and mitotic checkpoint genes as potential predictors of chemotherapy response in non-small-cell lung cancer
- Dihydropyrimidine dehydrogenase (Dpyd) gene polymorphism : portrait of a serial killer
- Impact of UDP- glucuronosyltransferase 1A haplotypes on irinotecan treatment
- Microarray profiling in breast cancer patients
- Role of the folate-pathway and the thymidylate synthase genes in pediatric acute lymphoblastic leukemia treatment response
- Pharmacogenomics in drug development : a pharmaceutical industry perspective
- Identification of pharmacogenomic biomarker classifiers in cancer drug development
- Toxicogenomics application to oncology drug development
- Strategies to identify pharmacogenomic biomarkers : candidate gene, pathway-based, and genome-wide approaches