Osteoporosis : methods and protocols /

Bibliographic Details
Other Authors: Westendorf, Jennifer J.
Format: Book
Language:English
Published: Totowa, N.J. : Humana, [2008]
Series:Methods in molecular biology ; 455.
Methods in molecular biology (Clifton, N.J.) ; 455.
Subjects:
Table of Contents:
  • Isolation and culture of rodent osteoprogenitor cells
  • Osteoclast culture and resorption assays
  • Assessing new bone formation in neonatal calvarial organ cultures
  • Detection of apoptosis of bone cells in vitro
  • In vivo parathyroid hormone treatments and RNA isolation and analysis
  • Assessment of bone formation assays : procedure and tissue analysis
  • Ossicle and vossicle implant model systems
  • Utility of the ovariectomized rat as a model for human osteoporosis in drug discovery
  • Orchidectomy models of osteoporosis
  • Gene delivery by adenoviruses
  • Lentivirus delivery of shRNA constructs into osteoblasts
  • Gene delivery by retrovirus
  • Chromatin immunoprecipitation assays : application of ChIP-on-chip for definging dynamic transcriptional mechanisms in bone cells
  • Identification of transcription factor target genes by ChIP display
  • Application of the laser capture microdissection technique for molecular definition of skeletal cell differentiation in vivo
  • Quantitative trait loci mapping
  • In situ nuclear organization of regulatory machinery
  • Bioluminescent imaging in bone
  • Micro-computed tomography : a method for the non-destructive evaluation of the three-dimensional structure of biological specimens
  • Fourier transform-infrared microspectroscopy and microscopic imaging
  • Assessment of the in vivo adaptive response to mechanical loading
  • Determination of bone's mechanical matrix properties by nanoindentation
  • fluid flow assays.