Fragile sites : new discoveries and changing perspectives /

Bibliographic Details
Other Authors:	Arrieta, Isabel, Penagarikano, Olga, Télez, Mercedes
Format:	Book
Language:	English
Published:	New York : Nova Biomedical Books, [2007]
Subjects:	Chromosome abnormalities. Chromosome Disorders > genetics. Chromosome Fragile Sites > genetics. Chromosome Fragility > genetics.

Table of Contents:

Fragile sites on human chromosomes
The molecular basis for the expression of common and rare fragile sites in the human genome
Common fragile sites : cytogenetics and cell cycle checkpoints
The implications of DNA replication in common fragile site expression
A common replication pattern underlies the fragility at fragile site regions
Role of DNA packaging on rare fragile site expression
Nucleosome assembly on DNA derived from rare fragile sites
AT-islands in fragile sites as Scaffold/Matrix-attachment regions (S/MARS)
Common fragile site genes
Fragile genes at common chromosomal fragile sites : roles in carcinogenesis
WWOX, the target of common chromosomal fragile site, FRA16D, is frequently dysregulated in multiple tumor types
Peptide encoded by an intron of the putative tumor suppressor gene testin of the common fragile site 7G is a cancer antigen recognized by citotoxic T lymphocytesand Kyogo Itoh
FRA11B and Jacobsen syndrome
FRAXA : the fragile X syndrome site
FMR1 premutation : a leading cause of inherited ovarian dysfunction
New developments in fragile X-associated tremor/ataxia syndrome (FXTAS)