Inhibitors of cyclin-dependent kinases as anti-tumor agents /

Bibliographic Details
Other Authors:	Smith, Paul J. (Paul James), 1953-, Yue, Eddy W.
Format:	Book
Language:	English
Published:	Boca Raton : CRC/Taylor & Francis, [2007]
Series:	CRC enzyme inhibitors series.
Subjects:	Cyclin-dependent kinases > Inhibitors. Cyclin-dependent kinases > Inhibitors > Therapeutic use > Testing. Cancer > Chemotherapy. Cyclin-Dependent Kinase Inhibitor Proteins > therapeutic use. Antineoplastic Agents > therapeutic use.

Table of Contents:

Cell cycle dynamics and the challenges for CDK targeting
Functional regulation of CIP/KIP CDK inhibitors
Mouse models to study the in vivo function of cyclin-dependent kinases in normal homeostasis and tumor development
Cyclin-dependent kinase inhibitors and vascular disease
Evaluation of CDK inhibitor selectivity : from affinity chromotography to yeast genetics
Development of CDK inhibitors as anticancer agents : from rational design to CDK4-specific inhibition
Three-dimensional structures of cyclin-dependent kinases and their inhibitor complexes
Cyclin-dependent kinase small molecular modulators for cancer therapy
(R)-roscovitine (CYC202, Seliciclib)
Development, selectivity, and application of paullones, a family of CDK inhibitors
Discovery of BMS-387032, a potent cyclin-dependent kinase inhibitor in clinical development
Oxindole inhibitors of cyclin-dependent kinases as anti-tumor agents
Indenopyrazoles as cyclin-dependent kinase inhibitors
Development of insolocarbazoles as cyclin D1/CDK4 inhibitors
Pyrazoles as efficient adenine-mimetic heterocycles for the discovery of CDK inhibitors
Pyrazolo[3,4-d]pyrimidie-4-ones : exploring the structural determinants of potency and selectivity in cyclin-dependent kinase inhibition
Cyclin-dependent kinase inhibitors and combination therapy : experimental and clinical status
CDK inhibitors as anticancer agsnts : perspectives for the future