Optimizing the "drug-like" properties of leads in drug discovery /
| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
New York, NY :
Springer,
[2006]
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| Series: | Biotechnology (Arlington, Va.)
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| Subjects: |
Table of Contents:
- Strategic use of preclinical pharmacokinetic studies and In Vitro models in optimizing ADME properties of lead compounds
- Role of mechanistic transport studies in lead optimization
- Metabolic activation-role in toxicity and idiosyncratic reactions
- Case history - use of ADME studies for optimization of drug candidates
- Solubility, solubilization and dissolution in drug delivery during lead optimization
- Lipid-based systems, drug exposure and lead optimization
- Biopharmaceutics modeling and the role of dose and formulation on oral exposure
- Application of physicochemical data to support lead optimization by discovery teams
- Computational models supporting lead optimization in drug discovery
- Prodrug strategies for improving drug-like properties
- The application of multivariate data analysis to compound property optimization
- Case history : toxicology biomarker development using toxicogenomics
- Predicting idiosyncratic drug reactions
- Elementary predictive toxicology for advanced applications
- The application of PK/PD modeling and simulations during lead optimization
- Early preclinical evaluation of brain exposure in support of hit identification and lead optimization
- Optimizing biomarker development for clinical studies at the lead optimization stage of drug development
- The relevance of transporters in determining drug disposition