What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice /

Bibliographic Details
Main Author:	Crawley, Jacqueline N.
Format:	Book
Language:	English
Published:	Hoboken, N.J. : Wiley-Interscience, [2007]
Edition:	Second edition.
Subjects:	Neurogenetics > Animal models. Transgenic mice > Behavior. Mice, Transgenic. Behavior, Animal. Disease Models, Animal. Genetics, Behavioral > methods. Mice, Knockout. Phenotype.

Table of Contents:

Designer mice : scope and sourcebooks
Of unicorns and chimeras : how to generate a transgenic or knockout mouse for behavioral phenotyping
General health : give your mouse a physical
Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures
Sensory abilities : olfaction, vision, hearing, taste, touch, nociception
Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention
Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis
Reproductive behaviors : sexual and parental behaviors
Social behaviors : social interaction, nesting, grooming, juvenile play, aggression
Emotional behaviors : animal models of psychiatric disorders : mouse models of fear, anxiety, depression, schizophrenia
Reward : self-administration of addictive drugs, conditioned place preference
Neurodevelopment and neurodegeneration : assaying behaviors in infant, juvenile, and aged mice
Putting it all together : choice of tests, order of testing, number of mice, equipment, housing and testing environment
The next generation : conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues.