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Experimental models of multiple sclerosis /

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Bibliographic Details
Other Authors: Lavi, Ehud, Constantinescu, Cris S.
Format: Book
Language:English
Published: New York, NY : Springer, [2005]
Subjects:
Multiple sclerosis.
Multiple sclerosis > Animal models.
Multiple Sclerosis.
Models, Animal.
Table of Contents:
  • Experimental allergic (autoimmune) encephalomyelitis (EAE)
  • EAE : history, clinical signs and disease course
  • Induction of EAE
  • Histopathology of EAE
  • Neuroantigens in EAE : myelin genes, proteins and non-proteins antigens
  • Adjuvants in EAE
  • The role of astrocytes in autoimmune disease of the central nervous system
  • Role of microglia and macrophages in EAE
  • The neuron and axon in EAE
  • Endothelial cells and adhesion molecules in EAE
  • Genetics of EAE
  • T lymphocytes in EAE : insights into the development and control of the autoreactive T cell
  • The role of complement in EAE
  • B cells and antibodies in EAE
  • Cytokines in EAE
  • The role of interferons in EAE
  • The role of growth factors in EAE
  • The chemokine system in EAE
  • Free radicals and EAE
  • Proteases and peptidases in EAE
  • The blood-brain-barrier in EAE
  • Immunomodulation in EAE : altered peptide ligands, tolerance and Th1/Th2
  • The role of costimulation in EAE
  • Epitope spreading in EAE
  • Apoptopic cell death in EAE : apoptosis of effector cells as a safe mechanism in the termination of an autoimmune inflammatory attack
  • Environmental influences in EAE
  • Hormonal and gender influences on EAE
  • EAE in primates
  • Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination
  • Histopathology in the Theiler's virus model of demyelination
  • TMEV and neuroantigens : myelin genes and proteins, molecular mimicry, epitope spreading and autoantibody-mediated remyelination
  • The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection
  • Immunogenetics, resistance and susceptibility to Theiler's virus infection
  • The role of T cells and the innate immune system in Theiler's virus demyelinating disease
  • Cytokines, chemokines and adhesion molecules in TMEV-IDD
  • Molecular determinants of TMEV pathogenesis
  • Nitric oxide in TMEV
  • Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination : apoptosis in TMEV infection
  • Corona virus-induced demyelination
  • Histopathology in coronavirus-induced demyelination
  • The role of astrocytes, microglia and endothelial cells in coronavirus-induced demyelination : induction of cytokines and other signaling mechanisms
  • Axons and neurons in coronavirus-induced demyelination
  • The role of T cells in corona-virus induced demyelination
  • The role of humoral immunity in mouse hepatitis virus induced demyelination
  • The role of T cell epitopes in coronavirus infection
  • Coronaviruses and neuroantigens : myelin proteins, myelin genes
  • Coronavirus-induced demyelination and remyelination : growth factor expression and function
  • Chemokines in coronavirus-induced demyelination
  • Coronavirus receptors
  • Apoptosis in MHV-induced demyelination
  • The role of metalloproteinases in corona virus infection
  • Molecular determinants in coronavirus MHV-induced demyelination
  • Demyelination induced by other viruses
  • Semliki Forest virus-induced demyelination
  • The pathogenesis of canine distemper virus induced demyelination : a biphasic process