Proteomics and protein-protein interactions : biology, chemistry, bioinformatics, and drug design /

Bibliographic Details
Other Authors: Waksman, Gabriel
Format: Book
Language:English
Published: New York : Springer Science+Business Media, [2005]
Series:Protein reviews ; v. 3.
Subjects:
Table of Contents:
  • Introduction
  • Yeast two-hybrid protein-protein interaction networks
  • The use of mass spectrometry in studying protein-protein interaction
  • Molecular recognition in the immune system
  • Computational methods for predicting protein-protein interactions
  • Protein-protein docking methods
  • Thermochemistry of binary and ternary protein interactions measured by titration calorimetry : complex formation of CD4, HIV gp120 and anti-gp120
  • Protein-protein recognition in phosphotyrosine-mediated intracellular signaling
  • Competitive binding of proline-rich sequences by SH3, WW and other functionally related protein domains
  • The structure and molecular interactions of the bromodomain
  • SMART drug design : novel phosphopeptide and ATP mimetic-based small molecule inhibitors of the oncogenic protein kinase pp60src (Src)
  • Disrupting protein-protein interaction : therapeutic tools against brain damage
  • A thermodynamic guide to affinity optimization of drug candidates