Apoptosis and cancer therapy : from cutting-edge science to novel therapeutic concepts /

Bibliographic Details
Other Authors: Debatin, K. M., Fulda, Simone
Format: Book
Language:English
Published: Weinheim : Wiley-VCH, [2006]
Subjects:
Table of Contents:
  • Vol.1
  • The role of CD95/CD95 ligand signaling in apoptosis and cancer
  • The TRAIL receptor-ligand system : biochemistry of apoptosis induction, therapeutic potential for cancer treatment and physiological function
  • Mechanisms of tumor necrosis factor-induced cell death
  • Cellular FLICE-inhibitory protein : an update
  • Dependence receptors and apoptosis
  • Role of mitochondrial proteins in apoptosis
  • Omi/HtrA2 : a mitochondrial serine protease regulating cellular life and death
  • Apoptosis-inducing factor
  • Caspases : agents of defense and destruction
  • The role of the apoptosome in apoptosis and cancer therapy
  • The role of the Bcl-2 protein family in tumorigenesis and cancer therapy
  • Bax, bak and bid : key mediators of apoptosis
  • The BH3-only proteins puma and noxa : two brothers in arms
  • Inhibitor of apoptosis proteins
  • Targeting the survivin pathway for rational cancer therapy
  • Nuclear factor-kB in apoptosis and tumorigenesis
  • Cell survival signaling through phosphoinositide 3-kinase and protein kinase B
  • Survival regulation by Ras and Raf
  • p53-mediated apoptosis : a multifaceted story
  • p73 affects cell fate and tumorigenesis
  • RB and cancer
  • Calcium signaling in apoptosis
  • Lysosomes and nonapoptotic pathways
  • The role of "eat me", "don't eat me" and "find me" signals for the efficient removal of apoptotic cells
  • Apoptotic cell clearance by macrophages : relevance to tumor pathogenesis
  • Mouse models in cancer research
  • Molecular diagnosis
  • Molecular imaging in cancer
  • Microarray-based expression profiling : from technological basics to diagnostic perspectives
  • Life and death decisions in response to stress
  • Hypoxia in cancer
  • Apoptosis induced by DNA-damaging agents
  • DNA repair
  • Therapeutic modulation of apoptosis in cancer therapy
  • Current therapeutic strategies targeting caspases in disease
  • Small-molecule inhibitory of the inhibitor of apoptosis proteins
  • Inhibition of the molecular chaperone heat shock protein 90 in cancer : consequences for the regulation of survival signaling and induction of cell death
  • Targeting the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway
  • Ceramide-signaling in apoptosis and cancer therapy
  • Histone deacetylase inhibitors : development as anticancer agents
  • Exploiting apoptosis pathways for glioblastoma therapy
  • Radiation therapy and apoptosis
  • Tumor angiogenesis
  • Vol.2
  • Mouse Models in cancer research
  • molecular imaging in cancer
  • Microarray-based expression profiling : from technological basics to diagnostic perspectives
  • Life and death decisions in response to stress
  • Hypoxia in cancer
  • Apoptosis induced by DNA-damaging agents
  • DNA repair
  • Therapeutic modulation of apoptosis in cancer therapy
  • Current therapeutic strategies targeting caspases in disease
  • Small-molecule inhibitory of the inhibitor of apoptosis proteins
  • Inhibition of the molecular chaperone heat shock protein 90 in cancer : consequences for the regulation of survival signaling and induction of cell death
  • Targeting the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway
  • Ceramide-signaling in apoptosis and cancer therapy
  • Histone deacetylase inhibitors : development as anticancer agents
  • Exploiting apoptosis pathways for glioblastoma therapy
  • Radiation therapy and apoptosis
  • Tumor angiogenesis