Vascular-targeted therapies in oncology /

Bibliographic Details
Other Authors:	Siemann, Dietmar W.
Format:	Book
Language:	English
Published:	Chichester, England ; Hoboken, NJ : John Wiley & Sons, [2006]
Subjects:	Cancer > Chemotherapy. Neovascularization inhibitors. Blood-vessels > Effect of drugs on. Neovascularization. Neoplasms > drug therapy. Angiogenesis Inhibitors > therapeutic use. Blood Vessels > drug effects. Drug Delivery Systems. Endothelial Cells > drug effects. Genetic Therapy > methods. Neovascularization, Pathologic.

Table of Contents:

Tumor vasculature : a target for anticancer therapies
Abnormal microvasculature and defective microcirculatory function in solid tumors
The role of microvasculature in metastasis formation
Development of agents that selectively disrupt tumor vasculature : a historical perspective
Morphologic manifestations of vascular-disrupting agents in preclinical models
Molecular recognition of the colchicine binding site as a design paradigm for the discovery and development of vascular disrupting agents
Combined modality approaches using vascular-disrupting agents
Vascular-targeting therapies and hyperthermia
Flavones and xanthenones as vascular-disrupting agents
Targeting inside-out phospholipids on tumor blood vessels in pancreatic cancer
Cadherin antagonists as vascular-targeting agents
Alphastatin : a pluripotent inhibitor of activated endothelial cells
Cationic lipid complexes to target tumor endothelium
Development of vascular-targeting cancer gene therapy
Vascular-disrupting strategies combined with bacterial spores targeting hypoxic regions of solid tumors
Imaging the effects of vascular-targeting agents
Clinical progress in tumor vasculature-disrupting therapies
Use of vascular-disrupting agents in non-oncology indications