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Biochemistry and molecular biology of antimicrobial drug action /

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This stimulating new edition of the well-respected title Biochemistry and Molecular Biology of Antimicrobial Drug Action primarily covers medically important antimicrobial agents, but also includes some compounds not in current medical use which have been invaluable as research tools in biochemistry...

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Bibliographic Details
Main Author: Franklin, T. J.
Other Authors: Snow, G. A.
Format: Book
Language:English
Published: New York : Springer, [2005]
Edition:Sixth edition.
Subjects:
Anti-infective agents > Physiological effect.
Microbial metabolism.
Microorganisms > Effect of antibiotics on.
Anti-Infective Agents > pharmacology.
Bacteria > drug effects.
Drug Resistance, Microbial.
Fungi > drug effects.
Viruses > drug effects.
Table of Contents:
  • The Development of Antimicrobial Agents, Past, Present and Future
  • The social and economic importance of antimicrobial agents
  • An outline of the historical development of antimicrobial agents
  • Reasons for studying the biochemistry and molecular biology of antimicrobial compounds
  • Uncovering the molecular basis of antimicrobial action
  • Current trends in the discovery of antimicrobial drugs
  • Scope and layout of the book
  • Vulnerable Shields-The Cell Walls of Bacteria and Fungi
  • Functions of the cell wall
  • Structure of the bacterial wall
  • Structure and biosynthesis of peptidoglycan
  • Antibiotics that inhibit peptidoglycan biosynthesis
  • Drugs that interfere with the biosynthesis of the cell wall of mycobacteria
  • The fungal cell wall as a target for antifungal drugs
  • Antimicrobial Agents and Cell Memberanes
  • Microbe killers: antiseptics and disinfectants
  • Cationic peptide antibiotics
  • Ionophoric antibiotics
  • Antifungal agents that interfere with the function and biosynthesis of membrane sterols
  • Inhibitors of Nucleic Acid Biosynthesis
  • Compounds affecting the biosynthesis and utilization of nucleotide precursors
  • Nucleoside analogues
  • Inhibitors of the reverse transcriptase of the human immunodeficiency virus
  • Antibacterial inhibitors of topoisomerases
  • Inhibitors of DNA-dependent RNA polymerase
  • Inhibition of nucleic acid synthesis by interaction with DNA
  • Inhibitors of Protein Biosynthesis
  • Ribosomes
  • Stages in protein biosynthesis
  • Puromycin
  • Inhibitors of aminoacyl-tRNA formation.