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Protein tyrosine kinases : from inhibitors to useful drugs /

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Bibliographic Details
Other Authors: Fabbro, D., McCormick, Frank, 1950-
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2006]
Series:Cancer drug discovery and development.
Subjects:
Protein-Tyrosine Kinases > therapeutic use.
Protein Kinase Inhibitors > therapeutic use.
Antineoplastic Agents.
Table of Contents:
  • Protein tyrosine kinases as targets for cancer and other indications
  • Inhibitors of signaling interfaces : targeting Src homology 2 domains in drug discovery
  • PI3-kinase inhibition : a target for therapeutic intervention
  • Src as a target for pharmaceutical intervention : potential and limitations
  • Activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia
  • JAK kinases in leukemias/lymphomas and multiple myeloma
  • Glivec® (Gleevec®, Imatinib, STI571): a targeted therapy for CML
  • Platelet-derived growth factor : normal function, role in disease, and applications of PDGF antagonists
  • Structural biology of protein tyrosine kinases
  • Testing of signal transduction inhibitors in animal models of cancer
  • Phosphoproteomics in drug discovery and development