Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists /
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Hoboken, N.J. :
J. Wiley,
2005.
|
| Series: | Methods of biochemical analysis ;
v. 46. |
| Subjects: |
Table of Contents:
- Why enzymes as drug targets?
- Enzyme reaction mechanisms
- Reversible modes of inhibitor interactions with enzymes
- Assay considerations for compound library screening
- Lead optimization and structure-activity relationships for reversible inhibitors
- Slow binding inhibitors
- Tight binding inhibitors
- Irreversible enzyme inactivators
- Appendix 1. Kinetics of biochemical reactions
- Appendix 2. Derivation of the enzyme-ligand binding isotherm equation
- Appendix 3. Serial dilution schemes