Adoptive immunotherapy : methods and protocols /

Bibliographic Details
Other Authors: Ludewig, Burkhard, Hoffmann, Matthias W.
Format: Book
Language:English
Published: Totowa, N.J. : Humana Press, [2005]
Series:Methods in molecular medicine ; 109.
Subjects:
Table of Contents:
  • Exploiting dendritic cells for active immunotherapy of cancer and chronic infection
  • A mathematical approach for optimizing dendritic cell-based immunotherapy
  • Delivery of tumor antigens to dendritic cells using biodegradable microspheres
  • RNA transfection of dendritic cells
  • Isolation and generation of clinical-grade dendritic cells using the CliniMACS system
  • Generation of clinical grade monocyte-derived dendritic cells using the CliniMACS system
  • Adenoviral transduction of dendritic cells
  • Generation of autologous peptide- and protein-pulsed dendritic cells for patient-specific immunotherapy
  • Phenotypical and functional characterization of clinical-grade dendritic cells
  • Dendritic cells in clinical trials for multiple myeloma
  • Identification of tumor-associated autoantigens with SEREX
  • Application of proteomics and protein analysis for biomarker and target finding for immunotherapy
  • Isolation and expansion of tumor-reactive cytotoxic T-cell clones for adoptive immunotherapy
  • Tracking adoptively transferred antigen-specific T-cells with peptide/MHC multimers
  • Gene transfer of MHC-restricted receptors
  • Immunotherapy with CTL restricted by nonself MHC
  • Designing TCR for cancer immunotherapy
  • Isolation and expansion of tumor-specific CD4+ T-cells by means of cytokine secretion
  • Methods for the ex vivo characterization of human CD8+ T subsets based on gene expression and replicative history analysis
  • Regulatory T cells in antitumor therapy : isolation and functional testing of CD4+CD25+ regulatory T-cells
  • Monoclonal antibody-based strategies in autoimmunity and transplantation
  • Producing bispecific and bifunctional antibodies
  • Antibody/cytokine fusion proteins for the therapy of cancer
  • Synthesis and biological evaluation of a paclitaxel immunoconjugate
  • Cytotoxic tumor targeting with scFv antibody-modified liposomes
  • Intravenous immunoglobin treatment for fibrosis, atherosclerosis, and malignant conditions
  • Study of T-cell costimulatory blockade in vivo at a single cell level
  • Stem cell transplantation : graft-mediated antileukemia effects
  • Influence of radiation protocols on graft-vs-host disease incidence after bone-marrow transplantation in experimental models
  • Induction of chimerism and tolerance using freshly purified or cultured hematopoietic stem cells in nonmyeloablated mice
  • Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation
  • Application of donor lymphocytes expressing a suicide gene for early GVL induction and later control of GVH reactions after bone-marrow transplantation