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Pharmacogenomics /

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Bibliographic Details
Other Authors: Kalow, Werner, Meyer, Urs A., 1938-, Tyndale, Rachel F., 1962-
Format: Book
Language:English
Published: New York : Taylor & Francis, 2005.
Edition:Second edition.
Series:Drugs and the pharmaceutical sciences ; 156.
Subjects:
Pharmacogenetics.
Drug Design.
Table of Contents:
  • Historical aspects of pharmacogenetics
  • Pharmacogenomics and the promise of personalized medicine
  • Pharmacogenetics of drug metabolism : two clinically important polymorphic enzymes, CYP2D6 and TPMT
  • Receptors
  • Pharmacogenetics of drug transporters
  • Variability in induction of human drug metabolizing enzymes
  • Pharmacogenetics and cardiac ion channels
  • Interethnic differences in drug response
  • Clinical perspectives
  • Regulatory perspectives on pharmacogenomics
  • Tools of the trade : the technologies and challenges of pharmacogenetics
  • Technologies for the analysis of single nucleotide polymorphism - an overview
  • Molecular diagnostics
  • Metabonomics
  • Multiplex minisequencing on microarrays : application to pharmacogenetics of antihypertensive drug response
  • MALDI-TOF MS : applications in genomics
  • Gene expression analysis in pharmacogenetics and pharmacogenomics
  • Proteomics
  • Haplotype structure and pharmacogenomics
  • Pharmacoepigenetics : from basic epigenetics to therapeutic applications
  • WWW bioinformatics resources
  • Pharmacogenomics : applied bioinformatics chapter
  • Mapping of disease loci
  • Positional cloning and disease gene identification
  • Genome variation influencing gene copy number and disease
  • General conclusions and future directions