Preclinical drug development /
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton :
Taylor & Francis,
2005.
|
| Series: | Drugs and the pharmaceutical sciences ;
v. 152. |
| Subjects: |
Table of Contents:
- The scope of preclinical drug development : an introduction and framework
- Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations
- Transgenic animals for preclinical drug development
- Pharmacokinetics/ADME of small molecules
- Pharmacokinetics/ADME of large molecules
- Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development
- Formulation and route of administration - influencing drug permeability and absorption
- Assessment of pharmacokinetics and drug activity : isolated organ systems and the membrane transporter family
- Alternate methods for assessing absorption, metabolism, and routes of elimination
- Toxicity evaluations : ICH guidelines and current practice
- Application of pathology in safety assessment
- Priniciples of toxicogenomics : implications for preclinical drug development
- Utilizing the preclinical databse to support clinical drug development