Death receptors in cancer therapy /

Bibliographic Details
Other Authors:	El-Deiry, Wafik S.
Format:	Book
Language:	English
Published:	Totowa, N.J. : Humana Press, [2005]
Series:	Cancer drug discovery and development.
Subjects:	Neoplasms > immunology. Neoplasms > therapy. Cell Death > immunology. Genetic Therapy > methods. Receptors, Tumor Necrosis Factor.

Table of Contents:

Mammalian cell death pathways : intrinsic and extrinsic
Resistance to apoptosis in cancer therapy
Structure of TNF receptors and their interactions with ligands
Death receptor signaling in embryonic ectodermal development adaptor proteins in death receptor signaling
Caspase activation by the extrinsic pathway
Death signaling and therapeutic applications of TRAIL
Death receptor mutations
Regulation of death receptors
Regulation of TRAIL receptor expression in human melanoma
Regulation of death receptors by synthetic retinoids
Role of p53 in regulation of death receptors
Proapoptotic gene silencing via methylation in human tumors
Regulation of death receptor-induced apoptosis by NF-kB and interferon signaling pathways : implications for cancer therapy
TRAIL in cancer therapy
Expression and regulation of death receptors in multiple myeloma and prostate carcinoma
Regulation of TRAIL-induced apoptosis by transcriptional factors
Sensitizing tumor cells by targeting death receptor signaling inhibitors
Ceramide, ceramidase, and FasL gene therapy in prostate cancer
Gene therapy targeting receptor-mediated cell death to cancers
Combination of chemotherapy and death ligands in cancer therapy