Metabonomics in toxicity assessment /

Handbook outlines the use of metabonomics in the safety assessment of new chemical entities.

Bibliographic Details
Other Authors: Robertson, Donald G., Lindon, John C.
Format: Book
Language:English
Published: Boca Raton, FL : Taylor & Francis, 2005.
Subjects:
Table of Contents:
  • An overview of metabonomics
  • Overview of biomarkers
  • NMR spectroscopy : principles and instrumentation
  • NMR spectroscopy of biofluids
  • ¹H magic angle spinning NMR spectroscopy of tissues
  • The application of metabonomics as an early in vivo toxicity screen
  • Strategies and techniques for the identification of endogenous and xenobiotic metabloites detected in metabonomic studies
  • Multi- and megavariate data analysis : finding and using regularities in metabonomics data
  • Use of metabonomics to study target organ
  • Physiological variation in laboratory animals and humans
  • Environmental applications of metabonomic profiling
  • Current challenges and future developments in metabonomics technology