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Protein degradation /

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Bibliographic Details
Other Authors: Mayer, R. J. (R. John), Ciechanover, A. (Aaron.), Rechsteiner, Martin
Format: Book
Language:English
Published: Weinheim : Wiley-VCH, ©2005-©2008.
Subjects:
Proteins > Metabolism.
Ubiquitin.
Proteins > metabolism.
Cell Physiological Phenomena.
Ubiquitin > physiology.
Table of Contents:
  • v. 1. Ubiquitin and the chemistry of life
  • Brief history of protein degradation and the ubiquitin system
  • N-terminal ubiquitination : no longer such a rare modification
  • Evolutionary origin of the activation step during ubiquitin-dependent protein degradation
  • RING fingers and relatives : determinators of protein fate
  • Ubiquitin-conjugating enzymes
  • The SCF ubiquitin E3 ligase
  • The structural biology of ubiquitin-protein ligases
  • The deubiquitinating enzymes
  • The 26S proteasome
  • Molecular machines for protein degradation
  • Proteasome regulator, PA700 (19S regulatory particle)
  • Bioinformatics of ubiquitin domains and their binding partners
  • The COP9 signalosome : its possible role in the ubiquitin system
  • v. 3 . Cell biology of the ubiquitin-proteasome system
  • Ubiquitin : a new player in the peroxisome field
  • The ubiquitin proteasome system and muscle development
  • The COP9 signalosome : structural and biochemical conservation and its roles in the regulation of plant development
  • Ubiquitin and protein sorting to the lyosome
  • ISG15-dependent regulation
  • The role of the ubiquitin-proteasome pathway in the regulation of the cellular hypoxia response
  • p97 and ubiquitin : a complex story
  • Cdc48 (p97) and its cofactors
  • Deubiquitinating enzymes, cell proliferation, and cancer
  • v. 4. Ubiquitin signaling and cancer pathogenesis
  • Regulation of the p53 tumor-suppressor protein by ubiquitin and ubiquitin-like molecules
  • The ubiquitin-proteasome system in Epstein-Barr Virus infection and oncogenesis
  • HECT ubiquitin-protein ligases in human disease
  • Ubiquitin-independent mechanisms of substrate recognition and degredation by the proteasome
  • Endoplasmic reticulum protein quality control and degredation
  • Interactions between viruses and the ubiquitin-proteasome system
  • The ubiquitin-proteasome system in Parkinson's Disease
  • The molecular pathway to neurodegeneration in Parkin-related Parkinsonism
  • Parkin and neurodegeneration