Biomaterials for delivery and targeting of proteins and nucleic acids /

Bibliographic Details
Other Authors:	Mahato, Ram I.
Format:	Book
Language:	English
Published:	Boca Raton : CRC Press, [2005]
Subjects:	Drug Delivery Systems. Polymers > therapeutic use. Biocompatible Materials > therapeutic use. Dosage Forms. Peptides > therapeutic use. Proteins > therapeutic use.

Table of Contents:

Structure, properties, and characterization of polymeric biomaterials
Step-growth and ring-opening polymerization
Copolymers, block copolymers, and stimuli-sensitive polymers
Polymer solution properties, micelles, dendrimers, and hydrogels
Protein conjungation, cross-linking, and PEGylation
Complement activation by injectable colloidal drug carriers
Biological membranes and barriers
Pharmacokinetics of protein- and nucleotide-based drugs
In vivo fate of polymeric gene carriers
Subcellular fate of proteins and nucleic acids
Stability of proteins and nucleic acids
Formulation, stability, and characterization of protein and peptide drugs
Micro- and nanoparticulate polymeric delivery systems for nucleic acid-based medicine
Liposomal delivery of protein and peptide drugs
Mechanisms of cellular drug resistance and strategies to overcome it
Transporters as molecular targets for drug delivery and disposition
Protein transduction domain as a novel tool for delivery of proteins, peptides, and nucleic acids
Introduction to therapeutic nucleic acids
Antisense and antigene oligonucleotides : structure, stability, and delivery
Artificial nucleic acid chaperones
Basic components of plasmid-based gene expression systems
Design elements of polymeric gene carriers