The p53 family : a subject collection from Cold Spring Harbor Perspectives in biology /
| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
Cold Spring Harbor, N.Y. :
Cold Spring Harbor Laboratory Press,
[2010]
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| Subjects: |
Table of Contents:
- The origins and evolution of the p53 family of genes
- The tumor suppressor p53 : from structures to drug discovery
- The isoforms of the p53 protein
- p63 and p73, the ancestors of p53
- Transcriptional regulation by p53
- Posttranslational modification of p53 : cooperative integrators of function
- The regulation of the p53-mediated stress response by MDM2 and MDM4
- Tied up in loops : positive and negative autoregulation of p53
- Tp53 mutations in human cancers : origins, consequences, and clinical use
- Clinical outcomes and correlates of TP53 mutations and cancer
- Single-nucleotide polymorphisms in the p53 signaling pathway
- Tumor suppressive functions of p53
- p53 regulation of metabolic pathways
- p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
- The role of p53 gene family in reproduction
- Using mice to examine p53 functions in cancer, aging, and longevity
- Mutant p53 gain-of-function in cancer
- Mouse models of p53 functions
- Zebrafish models of p53 functions
- Phylogeny and function of the invertebrate p53 superfamily
- P53-based cancer therapy
- Pathologies associated with the p53 response
- P53 research : the past thirty years and the next thirty years