Principles of hormone behavior relations /

Bibliographic Details
Main Author: Pfaff, Donald W., 1939-
Other Authors: Phillips, I. M. (Ian M.), Rubin, Robert T.
Format: Book
Language:English
Published: Amsterdam ; Boston : Elsevier Academic Press, [2004]
Subjects:
Table of Contents:
  • Characterizing the phenomena : hormone effects are strong and reliable
  • Hormones can both facilitate and repress behavioral responses
  • One hormone can have many effects : a single hormone can affect complex behaviors
  • Hormone combinations can be important for influencing an individual behavior
  • Hormone metabolites can be the behaviorally active compounds
  • There are optimal hormone concentrations : too much or too little can be damaging
  • Hormones do not "cause" behavior; they alter probabilities of response to given stimuli
  • History : hormone effects can depend on family, gender, and development
  • Familial/genetic dispositions to hormone responsivesness can influence behavior
  • The sex of the recipient can influence the behavioral response
  • Hormone actions early in development can influence hormone responsivenes in the CNA during adulthood
  • Puberty alters hormone secretion and hormone responsivity and heralds sex differences
  • Changes in hormone levels and responsiveness during aging affect behavior
  • Time : hormonal effects on behavior depend on temporal parameters
  • Duration of hormone exposure can make a big difference : in some cases longer is better, in other cases brief pulses are optimal for behavioral effects
  • Hormonal secretions and responses are affected by biological clocks
  • Space : spatial aspects of hormones administration and impact are important
  • Effects of a given hormone can be widespread across the body; central effects consonant with peripheral effects form coordinated, unified mechanisms
  • Hormones can act at all levels of the neuraxis to exert behavioral effects; the nature of the behavioral effect depends on the site of action
  • Mechanisms : molecular and biophysical mechanisms of hormone actions gives clues to future therapeutic strategies
  • In responsive neurons, rapid hormone effects can facilitate later genomic actions
  • Gene duplication and splicing products for hormone receptors in the CNS often have different behavioral effects
  • Hormone receptors and other nuclear proteins influence hormone responsiveness
  • Environment : environmental variables influence hormone/behavior relations
  • Hormone effects on behavior depend upon context
  • Behavioral/environmental context also alters hormone release
  • Evolution
  • Neuroendocrine mechanisms have been conserved to provide biologically adaptive body/brain/behavior coordination