Biology of IGF-1 : its interaction with insulin in health and malignant states /

Bibliographic Details
Other Authors: Bock, Gregory, Goode, Jamie
Format: Book
Language:English
Published: Chichester, U.K. ; Hoboken, NJ : John Wiley & Sons, 2004.
Series:Novartis Foundation symposium ; 262.
Subjects:
Table of Contents:
  • Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse
  • Physiology of the IGF system
  • Molecular basis of insulin action
  • IGF-1 and insulin as growth hormones
  • Insulin-like growth factors and neoplasia
  • Loss of IGF2 imprinting : mechanisms and consequences
  • Insulin and IGF-1 receptor trafficking and signalling
  • The mTOR/S6K signalling pathway : the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb
  • Structural biology of insulin and IGF-1 receptors
  • Genetic blockade of the insulin-like growth factor-I receptor for human malignancy
  • IGF-1 and prostate cancer
  • IGF-1 and breast cancer
  • IGFBPs and cancer
  • The IGF receptor as anticancer treatment target
  • Nutrition, insulin, IGF-1 metabolism and cancer risk : a summary of epidemiological evidence