Table of Contents:
  • The bacteria
  • Genome
  • What is a pneumococcus?
  • Comparative genomics of Streptococcus pneumoniae : intrastrain diversity and genome plasticity
  • Surface anatomy
  • Capsules
  • Choline-binding proteins
  • Pneumolysin and other virulence proteins
  • Microbial physiology
  • Cell wall hydrolases
  • Transformation
  • Host-microbe interactions
  • Exposure and colonization
  • Evolutionary and population biology of Streptococcus pneumoniae
  • Pneumococcal carriage
  • Epidemiology of pneumococcal disease
  • Mechanisms of carriage
  • Invasion and infection
  • Inflammation and host defense
  • Interactions of Streptococcus pneumoniae with the proteins of the complement pathways
  • A pathogenetic categorization of clinical syndromes caused by Streptococcus pneumoniae
  • Attachment and invasion of the respiratory tract
  • Pathogenesis of pneumococcal meningitis
  • Immunodeficiency and invasive pneumococcal disease
  • Treatment and prevention
  • Changing the ecology of pneumococci with antibiotics and vaccines
  • Pneumococcal infections : therapeutic strategies and pitfalls
  • Clinical relevance of antibiotic resistance in pneumococcal infections
  • Mechanisms for penicillin resistance in Streptococcus pneumoniae : penicillin binding proteins, gene transfer, and cell wall metabolism
  • Macrolide, quinolone, and other non-beta-lactam antibiotic resistance in Streptococcus pneumoniae
  • The humoral immune response to Streptococcus pneumoniae
  • New pneumococcal vaccines : basic science developments
  • Vaccine-induced immunity to pneumococcal infection