Inhibitors of protein kinases and protein phosphates /

Bibliographic Details
Other Authors: Alexander, Denis, Pinna, Lorenzo A., Cohen, Patricia T. W.
Format: Book
Language:English
Published: Berlin ; New York : Springer, [2005]
Series:Handbook of experimental pharmacology. v. 167.
Subjects:
Table of Contents:
  • Protein kinase inhibitors for the treatment of disease : the promise and the problems
  • Pt. I. General aspects of PKs inhibition
  • New design strategies for ligands that target protein kinase-mediated protein-protein interaction
  • Pt. II. Pharmacological potential and inhibitors of individual classes of protein kinases
  • The paullones : a family of pharmacological inhibitors of cyclin-dependent kinases and glycogen synthase kinase 3
  • Pharmacological potential of p38 MARK inhibitors
  • Inhibitors of PKA and related protein kinases
  • Inhibitors of protein kinase CK2 : structural aspects
  • Aminoglycoside kinases and antibiotic resistance
  • Pt. III. Pharmacological potential and inhibitors of individual classes of protein phosphatases
  • Protein tyrosine phosphatases as therapeutic targets
  • Structure-based design of protein tyrosine phsophatase inhibitors
  • Biological validation of the CD45 tyrosine phosphatase as a pharmaceutical target
  • Serine/threonine protein phosphatase inhibitors with antitumor activity
  • Pt. IV. Inhibitors in clinical use or advanced clinical trials
  • Clinical immunosuppression using the calcineurin-inhibitors ciclosporin and tacrolimus
  • Targeted therapy with imatinib : an exception or a rule?
  • Clinical aspects of imatinib therapy
  • Isoquinolinesulfonamide : a specific inhibitor of Rho-kinase and the clinical aspect of anti-Rho-kinase therapy
  • Discovery and development of Iressa : the first in a new class of drugs targeted at the epidermal growth factor tyrosine kinase