Functional neurobiology of aging /

Bibliographic Details
Other Authors: Mobbs, Charles V.
Format: Book
Language:English
Published: San Diego, CA : Academic Press, [2001]
Subjects:
Table of Contents:
  • Introduction to concepts in aging research
  • Age-specific rates of neurological disease
  • Nature versus nurture in the aging brain
  • Neurochemistry of receptor dynamics in the aging brain
  • Epidemiology of neural aging
  • Demography and epidemiology of age-associated neuronal impairment
  • Neuropsychology of human aging
  • Memory changes with aging and dementia
  • Histology of age-related cortical changes in humans
  • Types of age-related brain lesions and relationship to neuropathologic diagnostic systems of Alzheimer's disease
  • Morphological changes in human cerebral cortex during normal aging
  • Longevity and brain aging : the paradigm of centenarians
  • Alzheimer's disease
  • Regional and laminar patterns of selective neuronal vulnerability in Alzheimer's disease
  • Patterns of cortical neurodegeneration in Alzheimer's disease : subgroups, subtypes, and implications for staging strategies
  • Non-Alzheimer's age-associated dementing disorders
  • Vascular dementia
  • Frontotemporal dementias : from classification problems to pathogenic uncertainties
  • Progressive supranuclear palsy and corticobasal degeneration
  • Neurobiology of disorders with Lewy bodies
  • Amyotrophic Lateral Sclerosis/ Parkinsonism-dementia complex of Guam
  • In vivo imaging of aging brain
  • Brain energy metabolism : cellular aspects and relevance to functional brain imaging
  • Functional imaging in cognitively intact aged people
  • Functional brain studies of the neurometabolic bases of cognitive and behavioral changes in Alzheimer's disease
  • Biochemical correlates of memory impairments
  • Cholinergic basal forebrain systems in the primate central nervous system : anatomy, connectivity, neurochemistry, aging, dementia, and experimental therapeutics
  • Glutamate receptors in aging and Alzheimer's disease
  • Tau phosphorylation
  • Heredity basis of Alzheimer's disease and related dementias
  • Etiology, genetics, and pathogenesis of Alzheimer's disease
  • Rodent models of age-related memory impairments
  • Genetically engineered models of human age-related neurogenerative diseases
  • Nonhuman primate and other vertebrate models of brain aging
  • Cognitive aging in nonhuman primates
  • Brain aging in Strepsirhine primates
  • Age-related morphologic alterations in the brain of old world and new world antrhopoid monkeys
  • The study of brain aging in great apes
  • Neurobiological models of aging in the dog and other vertebrate species
  • Interventions
  • Estrogens and Alzheimer's disease
  • Cholinergic treatments of Alzheimer's disease
  • Anti-inflammatory and antioxidant therapies in Alzheimer's disease
  • Vision
  • The retina in aging and in Alzheimer's disease
  • Pathogenesis of glaucomatous optic neuropathy
  • Color vision, object recognition, and spatial localization in aging and Alzheimer's disease
  • Hearing
  • Anatomical and neurochemical bases of presbycusis
  • Age, noise, and ototoxic agents
  • Auditory temporal processing during aging
  • Neurophysiological manifestations of aging in the peripheral and central auditory nervous system
  • Genetics and age-related hearing loss
  • Animal models of presbycusis and the aging auditory system
  • The development of animal models for the study of presbycusis : building a behavioral link between perception and physiology
  • Rehabilitation for presbycusis
  • Chemical senses
  • Olfaction and gustation in normal aging and Alzheimer's disease
  • Locomotion : basal ganglia and muscular functions
  • Functional impairments in humans
  • Aging effects on muscle properties and human performance
  • Parkinson's disease : symptoms and age dependency
  • Pathology and biochemistry of aging and disease of basal ganglia
  • The basal ganglia dopaminergic systems in normal aging and Parkinson's disease
  • Huntington's disease
  • Animal models
  • Biochemical and anatomical changes in basal ganglia of aging animals
  • Homeostasis : hypothalamus and related systems
  • Reproduction and the aging brain
  • Male sexual behavior during aging
  • Sexual behavior in aging women
  • Factors influencing the onset of female reproduction senescence
  • Female sexuality during aging
  • Hypothalamic neuropeptide gene expression in postmenopausal women
  • Neuroendocrine aspects of female reproductive aging
  • Hypothalamic changes relevant to reproduction in aging male rodents
  • Metabolism and the aging brain
  • Regulation of energy intake in old age
  • Thermoregulation during aging
  • Biological rhythms and the aging brain
  • Sleep and hormonal rhythms in humans
  • Circadian rhythms and sleep in aging rodents
  • Glucocorticoid secretion and the aging brain
  • Glucocorticoids and the aging brain : cause of consequence?
  • Growth hormone, insulin-like growth factor-1, and the aging brain
  • Autonomic nervous system and the aging brain
  • The aged sympathetic nervous sytem
  • Appendix. Basic genetic concepts