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Artificial nucleases /

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Bibliographic Details
Other Authors: Zenkova, Marina A., 1955-
Format: Book
Language:English
Published: Berlin ; New York : Springer, [2004]
Series:Nucleic acids and molecular biology. 13.
Subjects:
Deoxyribonucleases.
Biomimetic Materials.
Enzyme Inhibitors.
Enzymes.
Oligonucleotides.
Ribonucleases.
Table of Contents:
  • DNA hydrolysis : mechanism and reactivity
  • Active site of ribonuclease A
  • Structural considerations concerning cleavage of RNA
  • Cleavage of RNA by imidazole
  • Principles of nucleic acid cleavage by metal ions
  • Allosterically controlled ribozymes as artificial ribonuclease
  • Small ribonuclease mimics
  • Copper-containing nuclease mimics : synthetic models and biochemical applications
  • RNA-cleaving oligonucleotide-peptide conjugates
  • Sequence selective artificial ribonucleases employing metal ions as scissors
  • Site-specific artificial ribonucleases : conjugates of oligonucleotides with catalytic groups
  • DNA and RNA cleavage of double-stranded DNA
  • Bleomycin-oligonucleotide conjugates as site-specific nucleases